Use of SPECT to examine DAT binding and Trafficking by Genotype in Cigarette Dependence of Male Smokers
Brief Description Of Study
Studies demonstrate that genetics may play a role in smoking behavior. We will use a brain imaging technique called single photon emission computerized tomography (SPECT/CT) to help us learn more about how genetics can influence your motivation to smoke. SPECT/CT is a special camera that uses a radiotracer called DaTscan that provides information about your brain. If we can understand how genetics and smoking behavior interact, we may be able to develop personalized treatment options that can help individuals quit.
Detailed Study Description
Total Maximum Compensation (includes double-booking): $506 Depending on subject and staff availability, you will be able to complete the study in 6 visits. This study will be completed after you have participated in two SPECT/CT scans. SPECT/CT scan days, begin at 8:30 AM and ends at 5:00 PM however, much of this time you will be able to relax. Scans can usually be scheduled within 3-5 weeks after consenting. There are 6 main parts. They are: 1. Consent Visit (about 1-1.5 hours) $31 2. Physical Evaluation (about 1-1.5 hours) $31 3. Psychological Evaluation (about 1-1.5 hours) 4. SPECT/CT Scan Day Smoking or “Sated Scan” (about 8 hours) $100 5. SPECT/CT Scan Day Smoke Free or “Withdrawal Scan” (about 8 hours) $150 6. Up to 2 visits as a back-up scan subject, $81 each visit **On Scan Days, you will report at 8:30 a.m.** o Smoking as usual SPECT: You will come to our center and we will accompany you to the Hospital of the University of Pennsylvania (HUP) to get an IV infusion. After the infusion, you will be given $10 to get lunch and will return with the technician to the Center. After 3-4 hours, you will be accompanied back to the hospital to get your SPECT scan. Before and after the scan, you will be given the opportunity to smoke a cigarette. You will smoke as usual throughout the day o Overnight abstinent SPECT: The midnight before the scan, you will no longer be permitted to smoke. In the morning, you will come to our center and we will test your recent smoking activity. The Tech will accompany you to HUP to get an IV infusion. After the infusion, you will be given $10 to get lunch and will return with the technician to the Center. After 3-4 hours, you will be accompanied back to the hospital to get your SPECT scan. You will not be allowed to smoke at any time on this day until all study procedures have been completed.
Additional Information About The Study
Post Scanning - Most of the imaging solution will wash out of your body through your urine within a few hours after the scan. Your body breaks down the remaining tracer over the next day or two. - Please note that the brain images are collected for research purposes only and are not of the appropriate quality or type to diagnose brain illnesses.