Hormone effects in smoking addiction
Brief Description Of Study
Healthy male and non-pregnant female smokers are invited to screen for study participation in a protocol examining the effect of the hormone progesterone on smoking cravings.
Detailed Study Description
Smokers between the ages of 18-50 who smoke at least 10 cigarettes per day will be asked to undergo a screening visit where they sign the informed consent form, complete structured clinical interviews and provide breath and urine samples which will be run for nicotine levels, a drug screen and pregnancy test (for women only). All qualified participants will be asked to participate in two 5-day long out-patient test phases where they will undergo 3 brain-imaging scans and remain abstinent from smoking. Participants can receive up to $800 for full study completion.
Additional Information About The Study
Eligible subjects must: Be female and male smokers, aged 18 to 50 years; Have a history of smoking daily for the past 12 months, 10-25 cigarettes daily; NOT be seeking treatment for nicotine dependence; (for women) have regular menses every 25-35 days; Be in good health as verified by medical history; (for women) NOT be pregnant as determined by pregnant screening, nor breast feeding, and using acceptable birth control methods other than hormonal contraceptives; NOT have a history of a major medical illness; NOT be using psychotropic medication (antidepressants, antipsychotics, or anxiolytics); NOT have a recent diagnosis (within previous year) and treatment for Axis I disorders (major depression, bipolar affective disorder, generalized anxiety disorder, PTSD, and panic disorder); NOT have a lifetime history of schizophrenia or a substance addiction disorder, except nicotine; NOT have substance abuse disorder within previous 2 years, except nicotine; (for women) NOT be using oral contraceptives; NOT be using any other tobacco products other than cigarettes, including smokeless tobacco and nicotine products; NOT have a known allergy to progesterone or peanuts (vehicle for micronized progesterone).