Investigating the use of non-invasive brain stimulation as a predictor of recovery in post-stroke Aphasia

Brief Description Of Study

Aphasia is a condition that occurs frequently following a stroke, and is characterized by an impairment in the ability to communicate. The Laboratory for Cognition and Neural Stimulation (LCNS) is conducting a research study which will explore the effectiveness of Transcranial Magnetic Stimulation (TMS) as a predictor of recovery in aphasic stroke patients. We will also explore whether theta-burst stimulation (TBS), a type of TMS, can induce improvements in speech, specifically naming.

Clinical Study Identifier: TX1040

Detailed Study Description

The main purpose of this study is to determine if language improvement following a stroke can be predicted by techniques like Transcranial Magnetic Stimulation (TMS) paired with Electromyography (EMG), language tasks, and genotyping. TMS is a non-invasive brain stimulation technique by which an insulated coil, consisting of copper wires and other electrical components, is held over the head to produce a brief electrical current in the underlying brain tissue; this technique is delivered by highly trained and experienced personnel in our lab. We will target different areas of your brain, one of which will be the area corresponding to a muscle group in your hand. We will collect Electromyography, or EMG for short, which is a method of non-invasive muscle activity recording, by placing small electrodes on different locations on your hand, like your thumb and forefinger. For assessing language improvement, you will also undergo a few sessions where you will perform language tasks that may be displayed on a computer screen or could involve producing verbal responses as directed by our lab personnel. Lastly, we will ask you to provide us with a saliva sample for genotyping. We are also interested in determining whether theta-burst stimulation,a form of repetitive TMS in which TMS pulses are delivered quite rapidly, can improve speech production.

Additional Information About The Study

INCLUSION/EXCLUSION CRITERIA: • You are over the age of 18 • The stroke must have occurred at least 6 months ago • The stroke must have occurred on the left-side of the brain • The stroke must be the cause of Aphasia symptoms • You must have been right-handed before the stroke • You CANNOT have a history of seizures, or family history of seizures • English must be your first language VISIT BREAKDOWN: • Visit 1: Screening and Informed consent (2 hours) • Visit 2: MRI scan [2 hour] • Visit 3: Language testing (1.5 hours) • Visits 4-5:Picture Naming (up to 3 hours each) • Visit 6: TMS + EMG + Saliva sampling (2 hours) • Visit 7: Theta Burst Stimulation + language tasks (1 hour) • Visit 8: Theta Burst Stimulation + language tasks (1 hour) COMPENSATION: Participants will be compensated $15 to $25 per hour, and up to $50 per visit for travel and parking. LAB WEBSITE:

Contact research investigator to learn more about this study by filling out the form below.

To: Research Study Investigator
Subject: I am interested in participating in your Research Study
Dear Investigator,
I'm interested in learning more about and participating in your research study named: Investigating the use of non-invasive brain stimulation as a predictor of recovery in post-stroke Aphasia
I am hoping to hear back from you and discuss details of the study

By clicking "Contact Research Team", your contact information will be sent directly to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.