Investigating the Impact of Childhood Adversity on Brain Activity in Post-Menopausal Women
Brief Description Of Study
The aim of this study is to further our understanding of the impact of prepubertal adverse childhood experiences on brain activation during performance of affective and cognitive processing and memory tasks in men post-menopausal women between the ages of 48 and 65. Using functional brain imaging, we will identify differences in brain activation during memory and attention tasks in order to further understand the impact of early life stress on cognition.
Detailed Study Description
Participants in this study will be asked to participate in two study visits, each lasting about 3 hours. At Visit 1, participants will sign the informed consent form, undergo structured clinical interviews and provide blood (females only) and urine samples for drug, pregnancy and hormone testing. At Visit 2 participants will be asked to undergo a 50-minute functional imaging scan. Inside the scanner participants will view a screen and will play games where they are asked to remember letters and faces. Participants are compensated $20 for totally qualifying for Visit 1 and $100 for Visit 2.
Additional Information About The Study
Men and women, ages 48-65, will be eligible for this study if they: Have no history of a psychiatric disorder within the previous year; Have no history of a psychotic disorder within lifetime; Have no history of substance abuse within the last 3 years; Are considered medically healthy; Have not taken hormonal contraceptives for at least 3 months; Have a negative urine drug screen; Are able to give written consent and are fluent in written and spoken English; Are right handed; Do NOT have a metallic implant; Are NOT claustrophobic.