MOXI: Males, Antioxidants, and Infertility

Brief Description Of Study

MOXI is a research study to examine whether antioxidants can improve abnormal semen parameters in couples with male-factor infertility. Eligible male participants will be randomized to either an antioxidant supplement or placebo for 3 months, followed by fertility treatment with ovarian stimulation and intrauterine insemination.

Clinical Study Identifier: TX1084

Detailed Study Description

MOXI Phase I will involve randomization to either an antioxidant supplement or placebo. This study is blinded, such that neither the participant nor the study team will know which treatment is assigned. After 3 months of treatment (with the assigned study drug), couples will be receive up to 3 consecutive cycles of female ovarian stimulation with an oral medication (clomiphene citrate), triggered ovulation with hCG, and a single intrauterine insemination (Phase II). Couples who conceive in either Phase I or Phase II will be followed through pregnancy and delivery. Male subjects will take their assigned study drug for at least 3 and up to 6 months.

Additional Information About The Study

Study subjects will be adult men in good health with at least 1 abnormal parameter on a semen analysis. Subjects must have a female partner with regular periods, normal ovulatory function, at least one patent fallopian tube, and normal uterine cavity. Eligibility will be determined by the research team during a screening phase, prior to randomization and Phase I. Most study related mediations, tests, and interventions will be provided, at no costs.

Contact research investigator to learn more about this study by filling out the form below.


To: Research Study Investigator
Subject: I am interested in participating in your Research Study
Dear Investigator,
I'm interested in learning more about and participating in your research study named: MOXI: Males, Antioxidants, and Infertility
I am hoping to hear back from you and discuss details of the study

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