Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
Brief Description Of Study
The purpose of this trial is to determine the efficacy and provide further safety data on glycemic control in stroke patients. The study population of approximately 1400 patients will include hyperglycemic acute ischemic stroke patients of either gender who are 18 years of age or older. They will have a history of type 2 diabetes and hyperglycemia or in the absence of diabetes, must have a baseline glucose levels greater than or equal to 150 g/dL. To be eligible treatment must begin within 3 hours of arrival to the Emergency department and within 12 hours of stroke symptom onset. Participation is limited to those with baseline NIHSS scores 3-22. Patients that meet all eligibility criteria will receive up to 72 hours of hyperglycemia control with IV insulin therapy or control therapy with subcutaneous insulin. Treatment will be given within 12 hours of symptom onset and is recommended, but not required, to begin within 3 hours of arrival to the emergency department.