Generation Study

Brief Description Of Study

The Generation study is a clinical research study for individuals ages 60 to 75 with an increased genetic risk of developing clinical symptoms of Alzheimer’s disease. The study is enrolling persons who have two copies of the APOE4 gene An employee of the investigative site or an immediate family member of an employee of the investigative site are not eligible.

Clinical Study Identifier: 99999999

Detailed Study Description

Who may be eligible to participate? • Individuals 60-75 years of age who are cognitively normal. • Participants must have a reliable study partner: a spouse, relative, or friend who knows the participant well and sees him or her often, who will attend some study visits, and who will provide information about the participant during the study. Genetic Disclosure Prior to screening, research participants will meet with a genetic counselor to learn their APOE4 genotype status. Screening, which may be spaced out over multiple visits, will determine eligibility. It includes: • a physical/neruological exam • medical history • medication review • electrocardiogram (ECG) • collection of blood and urine • tests of memory and thinking • brain MRI/PET scan Study Activity • This study is comprised of 23 visits over the course of 60 months at the Perelman Center for Advanced Medicine at the Hospital of the University of Pennsylvania. • Participants will receive the study drug six times in the first year and four times in each year after. • Visits can include cognitive testing, blood work, physical and neurological exams, MRI scans and PET scans. Participants will be reimbursed for time and travel.

Additional Information About The Study

For more information, please visit the following sites:

Contact research investigator to learn more about this study by filling out the form below.

To: Research Study Investigator
Subject: I am interested in participating in your Research Study
Dear Investigator,
I'm interested in learning more about and participating in your research study named: Generation Study
I am hoping to hear back from you and discuss details of the study

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