Efficacy of DE-MRI-Guided Ablation vs. Conventional Catheter Ablation of Atrial Fibrillation: The DECAAF II Study

Study Overview

DECAAF II is a prospective, randomized, multi-center trial of patients with persistent AF and presence of atrial brosis. After consenting to participate in the study, the subject will undergo a DE-MRI scan to assess for extent of atrial brosis. After verifying adequate quality of the DE-MRI study, subjects will be randomized to one of two study groups to receive conventional PVI ablation (Group 1) or PVI+brosis-guided ablation (Group 2), as summarized in Figure 1 on the following page. In Group 1, PVI ablation will be performed as recommended by the HRS consensus statement2 and physicians will be blinded to the pre-ablation MRI brosis results. In Group 2, physicians will receive the DE-MRI scan prior to the ablation procedure, will complete conventional PV isolation,and will also target left atrial brosis detected by MRI.

  • Study Identifier: 823595

Recruitment Status


Contact the research team to learn more about this study.

Fields marked with asterisk (*) are required

Please verify that you are not a bot.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.

Volunteer Sign up

Volunteer Sign-up

Participate in medical studies to develop new diagnostic and clinical treatments and improve current standards of care.

Sign Up Now!

If you need assistance finding a non-cancer study or if you have any questions, please email psom-ocr@pobox.upenn.edu