Primary Cell Core
Determination of B-cell responsiveness to the incretin hormones GLP-1 and GIP in Cystic Fibrosis (PRIME)
The mechanisms underlying cystic fibrosis related diabetes (CFRD) pathophysiology must be better defined if care for people with CFRD is to be optimized or if development of CFRD is to be interrupted. Detailed studies of insulin secretion in CF are required to achieve this goal since 1) subtle insulin secretion ...
The Type 1 Diabetes Exchange Clinic-based Registry Network
T1D Exchange is a nonprofit program dedicated to improving the lives of people touched by type 1 diabetes (T1D). This program has been developed in collaboration with government agencies, JDRF, ADA, the Helmsley Charitable Trust, Clinicians, industry and people living with T1D with the overall goal of improving health outcomes. ...
Evaluation of the Enteroinsular Axis in Cystic Fibrosis (CHOP IRB #: 12-009589)
Cardiovascular Inflammation Reduction Trial (CIRT): A randomized double-blind placebo controlled event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with type 2 diabetes or metabolic syndrome
This is an event-driven, multi-center, randomized, double-blind, placebo-controlled trial to determine whether methotrexate reduces heart attacks, strokes, or death in people who have already had at least one heart attack and have type 2 diabetes or metabolic syndrome. Metabolic syndrome is defined as a combination of problems including a large ...