Percutaneous Ventricular Restoration in Chronic Heart Failure due to Ischemic Heart Disease
This is a study of the Parachute Implant device in patients with heart failure. Patients in this study will be those with heart failure due to coronary artery disease. The patients will be randomly assigned to receive the implant device or to receive continued medical management for their heart condition. ...
RANDOMIZED EVALUATION OF VAD INTERVENTION BEFORE INOTROPIC THERAPY
REVIVE-IT is a two-part study consisting of a trial and a registry. The REVIVE-IT Trial is a prospective, randomized, open-label, multicenter trial, evaluating the HeartMate II® LVAS versus a control group consisting of optimal medical management (OMM) in selected non-inotrope dependent, ambulatory, moderately advanced heart failure patients who are not ...
Oral Iron Repletion effects ON Oxygen UpTake in Heart Failure: IRONOUT-HF
IRONOUT-HF is a multi-center, randomized, double-blinded, placebo-controlled superiority trial of oral Fe polysaccharide compared to matching placebo with the primary endpoint of change in peak VO2 measured by CPET at 16 weeks.
Medtronic Post-MI Remodeling Prevention Therapy
The purpose of this clinical study is to determine if electrical pacing can prevent cardiac remodeling (adverse changes in size, shape, and function of the heart) after injury to the heart following a heart attack. Patients who have had their first MI within 10 days of screening and have a ...
Attain StarFix Model 4195 LV Lead Extraction Study
The purpose of this study is to characterize the removability of the Attain StarFix®Model 4195 Left Ventricular (LV) Lead (StarFix®). The goal of the trial is to evaluate the lead removal success in patients that are indicated for left ventricular lead removal. This study is required by the Food and ...
Effect of Organic Nitrates and Hydralazine on Wave Reflections and Left Ventricular Structure and Function in Heart Failure with Preserved Ejection Fraction
The purpose of this study is to test the effect of prolonged therapy (24 weeks) with isosorbide dinitrate ± hydralazine on arterial wave reflections, exercise capacity, left ventricular (LV) mass/fibrosis and diastolic function in patients with Heart Failure and Preserved Ejection Fraction (HFPEF). This is a double-blind, placebo-controlled pilot randomized ...
REmission from Stage D Heart Failure (RESTAGE-HF)
This is a non-randomized, prospective, multi-center study. Forty subjects satisfying the inclusion and exclusion criteria listed below will be recruited at participating centers. Subjects will be recruited to the trial in a preliminary manner prior to LVAD implantation or within 4 weeks of LVAD implantation. Subjects will be followed for ...
AdaptResponse Clinical Investigation Plan
The purpose of the research study is looking at a new algorithm (step by step approach) for patients with heart failure who are indicated for an BiV (biventricular) pacing device.
A stem cell study for patients with Heart Failure-DREAM_HF
This is a study of an experimental study product cells called rexlemestrocel-L, which consists of Mesenchymal Precursor Cells (or MPCs). These cells are special cells that were obtained from the bone marrow of a healthy person or donor who donated bone marrow for the purpose of this study. The donor ...