Language And Cognitive Impairment In Parkinson's Disease
This study is designed to determine the changes in the brain that occur during conditions of verbal stimulation in patients who have Parkinson’s Disease and Parkinson’s Disease with Dementia or Dementia with Lewy Bodies.
Conceptual Processing in Alzheimer’s Disease
The purpose of this study is to evaluate memory, language and cognitive difficulties in patients with AD. AD is a neurological disease where a specific part of the brain is not functioning well. A clinical diagnosis of AD needs to be confirmed in all participants prior to participation in the ...
A randomised double-blind parallel group multicentre phase IIIb study to compare ticagrelor with clopidogrel treatment on the risk of cardiovascular death myocardial infarction and ischaemic stroke in patients with established Peripheral Artery Disease (EUCLID Examining Use of tiCagreLor In paD)
This study is designed to test the hypothesis that ticagrelor monotherapy when compared with clopidogrel monotherapy will reduce the incidence of atherothrombotic ischaemic events, as measured by the composite of CV death, MI, and ischaemic stroke in patients with established PAD. Patients will receive either 90 mg ticagrelor orally bd ...
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
The purpose of this trial is to determine the efficacy and provide further safety data on glycemic control in stroke patients. The study population of approximately 1400 patients will include hyperglycemic acute ischemic stroke patients of either gender who are 18 years of age or older. They will have a ...
Optical measurement of Cerebral Blood Flow Response after Ischemic Stroke
This study is a non-randomized, Phase 2 clinical trial designed to assess optical CBF response to bolus normal saline. Subjects will have had an ischemic stroke within 96 hours of enrollment and no contraindication to bolus normal saline. The study intervention will be a one hour monitoring session. There will ...
Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial
POINT is a randomized, double-blind, multicenter trial that aims to determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg of clopidogrel is effective in preventing major ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death) at 90 days when subjects are randomized within ...
A Double-Blind Placebo-Controlled Parallel-Group Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke (MILESTONE)
This study aims to determine the effect of two dose strengths of dalfampridine-ER (AMPYRA) on adult patients who have experienced an ischemic stroke and continue to have stable walking issues.
Multicenter randomized double-blind double-dummy active-comparator event-driven superiority phase III study of secondary prevention of stroke and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS) comparing rivaroxaban 15 mg once daily with aspirin 100 mg (NAVIGATE ESUS)
This randomized trial will evaluate the use of rivaroxaban vs. aspirin in reducing the risk of recurrent stroke on patients with a recent embolic stroke of undetermined source. Subjects must be 18 or over and have had an ESUS within 6 months of study enrollment.
Investigating the use of non-invasive brain stimulation as a predictor of recovery in post-stroke Aphasia
Aphasia is a condition that occurs frequently following a stroke, and is characterized by an impairment in the ability to communicate. The Laboratory for Cognition and Neural Stimulation (LCNS) is conducting a research study which will explore the effectiveness of Transcranial Magnetic Stimulation (TMS) as a predictor of recovery in ...
Connected Health Blood Pressure Monitoring In Stroke and TIA Patients (CHAMPS)
This study aims to assess adherence with home blood pressure monitoring in hypertensive patients with a history of stroke to determine if a social incentive improves adherence with monitoring. Adult patients who have a history or stroke and uncontrolled hypertension may be eligible for this study. After enrollment, patients will ...